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pentobarbital will lower the level or effect of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Powerful or moderate CYP3A4 inducers substantially lower guanfacine plasma concentrations and elimination 50 %-life.pentobarbital will lower the level or result of tadalafil by impacting hepatic/intest